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A study was conducted to investigate the use of multiple implant-laden contact lenses (IM) for the management of elevated intraocular pressure in glaucoma patients. The IM lenses were designed to passively deliver bimatoprost, timolol, and hyaluronic acid at therapeutic doses, reducing the risk of side effects associated with high-dose eye drop solutions. The study found that the implant lenses showed sustained release of drugs over 72 hours and a reduced burst release compared to traditional eye drop therapy, resulting in a prolonged reduction in intraocular pressure. The study demonstrated the potential of implantation technology through contact lenses for the treatment of glaucoma.
This chapter focuses on the use of combinatorial drug delivery for advanced stage cancer treatment. It explains how the use of multiple drugs or a combination of chemo- and gene therapeutic agents is becoming a common part of cancer treatment strategies. Carbon-based nanocarriers, such as carbon nanotubes, graphene derivatives, and dendrimers, are being explored as potential delivery platforms for these drugs. The functionalization of these nanocarriers with polymers can improve targeting and biocompatibility. The chapter highlights the use of carbon-based nanocarriers as single carriers for multiple payloads, and discusses the challenges and future perspectives of this approach.
The study aimed to investigate the influence of contact lens (CL) materials on the attachment of human coronaviruses (HCoV-229E and HCoV-OC43) and the effectiveness of a rub and rinse step to remove the viruses. The binding rates of the viruses to 8 soft CL materials and 4 rigid gas permeable materials were analyzed. The study found that around 102 to 103 infectious viral particles were recovered from each CL material. Although some materials were more prone to coronavirus adhesion, all materials were easily decontaminated with a simple saline rinse step. CL care products containing hydrogen peroxide and povidone-iodine effectively removed virus contamination from CL surfaces without the need for a rub and rinse step. However, a full regimen including a rub and rinse step is necessary when using CL care products based on non-oxidative systems.
